Frentiu FD, Robinson J, Young PR, McGraw EA & O'Neill SL (2010)

Wolbachia-mediated resistance to dengue virus infection and death at the cellular level.

PLoS ONE 5(10) e13398

The paper details the development of a mosquito cell line-based model to dissect the functional and cellular mechanisms of Wolbachia-mediated viral inhibition. We show that cell lines infected with Wolbachia display limited dengue virus replication and protection from virus-induced mortality. The extent of viral inhibition is strongly correlated with Wolbachia density per cell, suggesting competition for cellular resources may underlie this phenotype.

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