Saijo Thomas, Jiyoti Verma, Megan Woolfit, Scott L. O’Neill
Wolbachia-mediated virus blocking in mosquito cells is dependent on XRN1- mediated viral RNA degradation and influenced by viral replication rate
PLoS Pathog 14(3): e1006879
This study examines the various stages in the DENV infection process to better understand the mechanism of Wolbachia-mediated virus blocking (WMVB). The results suggest that infection with Wolbachia does not inhibit DENV binding or cell entry, but reduces virus replication. In contrast to a previous report, researchers observed a similar reduction in replication of West Nile virus (WNV). This reduced replication is associated with rapid viral RNA degradation in the cytoplasm.