Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia a quasi-experimental trial using controlled interrupted time series analysis

Aedes aegypti mosquitoes are the primary vectors of dengue, Zika and chikungunya viruses. Of these, dengue is the most common arboviral infection of humans. Indonesia has among the highest dengue case burden, with an estimated 10 million clinical cases and 3000 deaths each year. The annual per capita incidence is estimated at 36–44 symptomatic cases per 1000 population1,2 with a resultant cost in excess of USD $2 billion per annum3. Yogyakarta is typical of many cities in Indonesia; dengue is endemic with a seasonal peak between November and May. The high force of infection in Yogyakarta is evidenced by the hospitalised dengue case burden and high seroprevalence of dengue virus (DENV) neutralising antibodies (68%) in children 1–10 years.

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